Jimmy's atoms accidentally get switched with Carl's hamster so that he has the head of a human boy and the body of Carl's hamster. Jimmy, Carl, and Sheen go to Retroland at midnight so they can prove that a phantom doesn't haunt the place. But thanks to an unexpected power-surge, Jimmy and Cindy's minds are being switched. Publicly humiliated by Cindy yet again, Jimmy comes up with an invention that will allow him to read her mind. After Cindy tricks him into losing a sure-win at the race, Jimmy, seeking revenge, uses advantage of his shoes' invisibility effect to play pranks on the students, leading to trouble when he ends up stuck in fast running mode. Wanting to beat Cindy in a relay race at their elementary school, Jimmy invents super shoes that make him run faster than anyone else. Jimmy, Carl, and Sheen form a rock band so they can beat Cindy and Libby in the school talent show, but their egos soon get out of control. He later must find a way to melt the large amounts of snow and ice. Jimmy freezes Retroville on a hot day, sending the town into a second ice age. Fowl makes Jimmy and Cindy partners for their project.Д¬arl is having problems due to his nightmares and convinces Jimmy to go inside his dream to see what happens that makes him so scared. Jimmy, Carl, Sheen, and Cindy go underwater in a submarine to look for a treasure after Ms. The Neutrons get rich after Jimmy goes back in time to convince his dad to invest in McSpanky's for the encyclopedia set. When Granny Neutron visits while his folks are away, Jimmy accidentally turns her into a baby and must look after her while simultaneously working on an antidote so he can change her back to normal before his folks return home with the help of Cindy. Wanting to prove Cindy wrong, Jimmy brings Thomas Edison to the present, but is unable to take him back when Edison falls for Ms. When his friends are too busy to help him or hang out, Jimmy invents a little brother robot who soon becomes annoying. Jimmy invents a robot salesman in order to win a candy-selling contest against Cindy. Jimmy tries to get back his genius self and invent something fast before the meteor destroys Earth. However, his brain-draining invention glitches and instead causes him to become unintelligent and goofy, just when a meteor is about to hit Earth.

Jimmy becomes a normal boy because his classmates are angered of how smart he is. But after a malfunction, Jimmy's pants, along with Carl's pants, Sheen's pants and Cindy's pants, start to walk on their own and plan to take over the world. HowellДЄfter being punished by Judy for not picking up his pants, Jimmy invents a chip that'll make his pants put themselves away so his punishment will be lifted. In celebration of the film's 20th anniversary, Jimmy Neutron: Boy Genius will return to theaters for two days on November 7 and 12, 2021. WeissДЄn extremely intelligent ten-year-old boy and his friends must rescue their parents after they are abducted by aliens. The episode ends with Carl coming into the house and asking if he can use their toilet. While Hugh and Judy Neutron are talking about Jimmy returning home, Jimmy thwarts the Yolkians plot, and returns home. Jimmy (voiced by Debi Derryberry) runs away after his parents ground him for launching Carl (voiced by Rob Paulsen) off the roof, but soon discovers King Goobot and his henchman, Ooblar, trying to take over the world.

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